Why Chemically Defined Media (CDM) Requires Higher Raw Material Purity?

As regulatory requirements for biological products increase, traditional serum-containing media have been largely replaced by Chemically Defined Media (CDM).

Losing the "Umbrella" of Serum

In traditional media, serum contains large amounts of albumin, which have strong "buffering" and "detoxifying" abilities. In CDM, these protective proteins no longer exist. Any trace toxic impurities introduced by raw materials will act directly on cells without buffering.